2014年11月4日讯 /生物谷BIOON/ --阿斯利康（AstraZeneca）近日宣布，已完成对Almirall专有呼吸系统业务的收购。此次收购耗资21亿美元，包括一笔8.75亿美元的预付款，以及高达12.2亿美元的研发、上市及销售相关的里程碑款项，此外，阿斯利康还同意支付各种与销售相关的支出。
正如此前所宣布的，该笔交易将使阿斯利康获得Almirall专有呼吸系统业务的开发和商业化权利，包括拥有来自Almirall现有合作伙伴关系的收入流及研发管线中实验性新颖疗法的权利。Almirall公司的呼吸系统专营权包括Eklira（aclidinium，阿地尼亚）、LAS40464（阿地尼亚+福莫特罗复方药，已在欧盟申请注册，在美国处于在研）、LAS100977（abediterol，一种每日一次的长效β2受体激动剂LABA，处于II期临床）、处于临床前开发（LAS191351，LAS194871）和I期临床（LAS190792）的M3拮抗剂β2受体激动剂（MABA）平台、多个临床前项目。
根据协议，Almirall旗下专注于创新专有设备研发的子公司Almirall Sofotec，也已转让给阿斯利康。
此次业务合并，将使阿斯利康立即获得市场收入，将有助于促进公司收入增长的恢复。Almirall公司新颖的呼吸资产及其设备能力，将进一步加强阿斯利康的呼吸系统产品组合，包括Symbicort和Pulmicort及在研的实验性药物。
而药物Eklira和LAS40464及专有的Genuair设备等资产，将使阿斯利康能够为患者提供横跨一系列分子和复方药物的干粉吸入器及计量吸入器设备的治疗选择。
阿斯利康首席执行官Pascal Soriot表示：“与Almirall之间的战略交易，将为公司强大的呼吸系统专营权带来战略性及长期价值。呼吸系统专营权是阿斯利康的主要增长平台之一，此次交易将使公司即刻获得不断增长的产品收入。通过结合自身的创新组合，并充分利用公司的全球科学和商业能力，我们将加强在哮喘和慢性阻塞性肺病（COPD）整个护理范畴的应对能力。我们非常欢迎Almirall的员工加入我们的队伍。”
英文原文：AstraZeneca completes strategic transaction with Almirall in respiratory disease
AstraZeneca today announced that it has completed the strategic transaction to transfer the rights to Almirall’s respiratory franchise to the company.
As previously announced, the business combination gives AstraZeneca ownership of the rights for the development and commercialisation of Almirall’s proprietary respiratory business, including rights to revenues from Almirall’s existing partnerships, as well as its pipeline of investigational novel therapies.
The franchise includes Eklira® (aclidinium); Duaklir® Genuair®, the combination of aclidinium with formoterol (LAMA/LABA) that has received a positive opinion from the CHMP in the EU and is being developed in the US; LAS100977 (abediterol), a once-daily long-acting beta2-agonist (LABA) in Phase II; an M3 antagonist beta2-agonist (MABA) platform in pre-clinical development (LAS191351, LAS194871) and Phase I (LAS190792); and multiple pre-clinical programmes. Almirall Sofotec, an Almirall subsidiary focused on the development of innovative proprietary devices, also transfers to AstraZeneca.
From completion, AstraZeneca will access all on-market revenues, contributing to the company’s return to growth. The company expects the transaction to be neutral to Core EPS in 2015 and accretive from 2016. The transaction will have no impact on AstraZeneca’s guidance for 2014.
Pascal Soriot, Chief Executive Officer, AstraZeneca, said: “I am delighted to welcome our Almirall colleagues to AstraZeneca. Respiratory disease is one of our company’s key therapeutic areas, and the combination of these exciting portfolios reinforces our long-term commitment to patients with asthma and COPD. Our expanded product and device offering will enable us to bring better treatment options to patients.”
Following the completion of the transaction, AstraZeneca will pay Almirall approximately $875 million of initial consideration, subject to adjustment for working capital, and up to $1.22 billion in development, launch and sales-related milestones. AstraZeneca has also agreed to make various sales-related payments.