2015年4月7日讯 /生物谷BIOON/ --根据全球知名市场调研公司GBI Research发布的最新研究报告，未来几年（2014-2020），全球结直肠癌（CRC）治疗市场将保持小幅稳定增长，到2020年达到94亿美元，在预测期内的复合年增长率（CAGR）为1.8%，该市场在2013年市值83亿美元。
报告指出，这一增长将主要发生于8个主要发达国家，包括美国、日本、加拿大、欧洲5国（英国、法国、德国、西班牙、意大利）。在2013年，美国在全球结直肠癌（CRC）治疗市场中的份额最大，占据44.1%，其次是日本（14.7%）和德国（11.9%），西班牙（4.1%）市场份额最低。这些国家预计将以较慢的速度增长，日本除外，该国将以较快的速度增长（CAGR为5%）。
报告指出，在预测期间，罗氏（Roche）重磅药物安维汀（Avastin，通用名：bevacizumab，贝伐单抗）和默克（Merck KGaA）重磅药物爱必妥（Erbitux，通用名：cetuximab，西妥昔单抗）在主要市场的专利到期，将促进低价生物仿制药的市场接纳，这将限制全球结直肠癌治疗市场的增长。罗氏化疗药物希罗达（Xeloda，通用名：capecitabine，卡培他滨）仿制药在主要市场的上市，预计也将限制全球结直肠癌治疗市场的增长。
然而，GBI分析师Saurabh Sharma指出，即便安维汀（Avastin）专利到期，该药仍将保持其全球结直肠癌（CRC）治疗市场的领先地位，直至2020年。Saurabh解释称，当前Avastin正被广泛用于结直肠癌的一线和二线治疗，无论患者的K-Ras状态如何。尽管已有相关表皮生长因子受体（EGFR）抑制剂上市，用于治疗K-Ras野生型肿瘤；但Avastin在转移性K-Ras野生型及突变型肿瘤治疗市场中仍将保持其一贯的统治地位。
报告指出，拜耳的口服抗癌新药Stivarga（regorafenib）预计将成为推动全球结直肠癌（CRC）治疗市场增长的最大动力之一，这主要是该药预期的临床治疗扩展，作为一种维持性治疗药物用于已切除肝转移的转移性结直肠癌（mCRC）的一线治疗。Stivarga是一种口服多激酶抑制剂，目前在美国、欧盟、日本等主要市场上市。另外，日本大鹏药业的抗癌药Lonsurf（TAS-102）于2014年在日本获批用于三、四线治疗，安进的单抗药物Vectibix（帕尼单抗，panitumumab）也获美国和欧盟批准用于一线治疗。这些新药的市场接纳，将促进全球治疗市场的增长。
报告还指出，在预测期内（2014-2020），有数个新的管线药物预计将登陆市场，包括礼来的单抗药物Cyramza（ramucirumab）、勃林格殷格翰的三联血管激酶抑制剂nintedanib、XBiotech公司的单抗药物Xilonix。然而，这些药物将进入竞争非常激烈的二线及三四线治疗，不会对整个市场产生大的影响。而目前已上市的品牌药，由于被纳入更早期和更有利可图的一线治疗，将继续享有市场统治地位。
英文原文：Colorectal Cancer Treatment Market Value to Hit $9.4 Billion by 2020, says GBI Research
The value of the Colorectal Cancer (CRC) therapeutics market will increase moderately, from $8.3 billion in 2013 to $9.4 billion by 2020, representing a Compound Annual Growth Rate (CAGR) of 1.8%, according to business intelligence provider GBI Research.
The company’s latest report* states that this growth, which will occur across eight major developed countries, namely the US, UK, France, Germany, Spain, Italy, Japan and Canada, will be limited by the patent expirations of Avastin and Erbitux during the forecast period, which will prompt the uptake of lower-priced biosimilar versions of these drugs.
However, Saurabh Sharma, Senior Analyst for GBI Research, says that despite its patent expiration, Avastin is expected to retain its market-leading position in the global CRC space through to 2020.
Sharma explains: “Avastin is heavily prescribed in both first- and second-line settings, regardless of the patient’s K-Ras status. Its dominance is consistent across both the metastatic K-Ras wild-type and mutation-positive settings, despite the availability of epidermal growth factor receptor inhibitors for the treatment of K-Ras wild-type disease.
“Additionally, Stivarga is expected to be one of the biggest drivers of growth in the CRC market, due primarily to its anticipated line extension as a maintenance treatment in the first-line metastatic setting for patients with resected liver metastases.”
The analyst adds that while multiple new pipeline agents are expected to be launched in the CRC therapeutics market over the forecast period, none of these drugs will have a dramatic impact on the overall arena.
Sharma continues: “The currently marketed brands will continue to enjoy dominance due to their incorporation in the earlier and more lucrative lines of treatment.
“A number of new agents are likely to enter the market, including the anti-angiogenesis inhibitors Cyramza and nintedanib. However, these drugs will enter the competitive second- and later-line metastatic segments of the CRC therapeutics space.”